FOXO3 gene linked to human longevity

Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13987–13992.
Published online 2008 September 2. doi: 10.1073/pnas.0801030105
PMCID: PMC2544566
Copyright © 2008 by The National Academy of Sciences of the USA
FOXO3A genotype is strongly associated with human longevity
Bradley J. Willcox,*†‡§ Timothy A. Donlon,*¶ Qimei He,* Randi Chen,*† John S. Grove,*¶‖ Katsuhiko Yano,*† Kamal H. Masaki,*†‡ D. Craig Willcox,*** Beatriz Rodriguez,*†‡ and J. David Curb*†‡
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135). Long-lived men also presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations.


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2 Responses to FOXO3 gene linked to human longevity

  1. kurtu5 says:

    Aubrey de Grey thinks SENS has a 50 per cent chance of success within 25 years

  2. kurtu5 says:

    Oh and one other thing. We have talked about a site that has some sort of longevity theme…

    The lingo around Aubry is “Escape Velocity”. If you can stay alive to a certain date and have a certain baseline quality of health, then you can take advantage of cheap commercially available drugs to stave off death until the total cure is found. This is probably around the time when computers can do complete simulations of cells trivially. Until then, its a constant battle to stave of the reaper.

    Now, what website allows you to sign up, create health profiles, get targeted commercial ads for longevity drugs, post healthy choices socially(like where to find good local food), track new developments, track new speculations, track their personal escape velocity? What site has this?

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