Following Maria

So I’ve been recently following Maria here about longevity ideas….

And I’m kind of hoping that a race to cure baldness, might push some money into aging research. After all, there has to be money in a baldness cure…

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Im used to seeing research on slowing aging, now Im seeing experiments on *reversing* some aging processes

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Aging Process Slowed in Fruit Flies, PCG-1 ?

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Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology

Seeing that there are 10 times as many foreign cells for each human cell, this might open a pathway for custom engineering of metabolism among other things.  How many gates can one fit in a bacterium?

To date, a number of synthetic gene circuits1112131415161718192021 have been constructed to perform various digital logic functions and have demonstrated the great potential of using biological computational circuits10222324 to customize cell signalling. However, most of these gene circuits are not modular (that is, they are limited by having to use specific inputs and outputs) or are not insulated from their host chassis (that is, they are limited by having to operate in a specific genetic background to avoid potential cross-talk or at the cost of affecting the host genetic machinery). These limitations prevent their reuse and rapid incorporation into larger biological systems to achieve more complex logic functions. Ideally, a genetic logic device should be modular and orthogonal to their host chassis to facilitate its reuse and reliability in different contexts.

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FOXO3 gene linked to human longevity

Proc Natl Acad Sci U S A. 2008 September 16; 105(37): 13987–13992.
Published online 2008 September 2. doi: 10.1073/pnas.0801030105
PMCID: PMC2544566
Copyright © 2008 by The National Academy of Sciences of the USA
FOXO3A genotype is strongly associated with human longevity
Bradley J. Willcox,*†‡§ Timothy A. Donlon,*¶ Qimei He,* Randi Chen,*† John S. Grove,*¶‖ Katsuhiko Yano,*† Kamal H. Masaki,*†‡ D. Craig Willcox,*** Beatriz Rodriguez,*†‡ and J. David Curb*†‡
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135). Long-lived men also presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations.

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Finally a use for mosquitos

isolate antigenic proteins that confer immunity to microbes. sequence the amino acids that form that protein, and crate a cDNA that will result in that protein, add stop codons, start codons and dna polymerase binding sites for mosquito. Add this to mosquito larvae eggs. Put a marker gene with it so you can select the mosquitos that have been transformed. Better yet, add genes homogous to mosquito salviary proteins. Select for mosquitos that express the marker.
Repeat with new antigens until mosquito is a flying immunity program. You could have free vaccinations for a host of diseases free, once you get going.
Problems: who would fund this, if its free to the consumer. What about mutations.

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